Study Detail

TitleSurvey of short RNA expression after interference of RNAs expressed from retrotransposons
Study TypeTranscriptome Analysis
Abstract To assess the regulatory role of LINE-1 teRNAs in myogenesis - and its disruption by LINE-1 RNAi - we generated genome-wide maps of transcriptional activity in C2C12 muscle cells (myoblasts) poised for differentiation. 18 million Cap Analysis Gene Expression (CAGE .. [more]
Description Here, we report in detail the first use of RNA interference against LINE-1 transposed element RNAs, in an effort to ascertain their functional significance. Using mouse myoblasts as a model system, we observed clear phenotypic consequences post knock-down of LINE- .. [more]
Center NameRIKEN_OSC