Study Detail

TitleEzh2 augments leukemogenecity by reinforcing differentiation block in acute myeloid leukemia.
Study TypeEpigenetics
Abstract EZH2, a catalytic component of the polycomb repressive complex (PRC) 2, trimethylates histone H3 at lysine 27 (H3K27) to repress the transcription of target genes. Although EZH2 is overexpressed in various cancers including hematological malignancies, the role of EZH2 in acute myeloid leukemia (AML) .. [more]
Description Role of Ezh2 in acute myeloid leukemia.
Center NameCHIBA_U