Study Detail

TitleConcurrent depletion of Ezh2 and Tet2 propagates epigenomic alterations and accelerates development of myelodysplasia in mice
Study TypeEpigenetics
Abstract Inactivating somatic mutations in polycomb-group (PcG) genes, such as EZH2 and ASXL1, occur frequently in patients with myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN), and MDS/MPN overlap disorders. Here we show that hematopoietic-restricted deletion of Ezh2 recapitulates MDS/MPN .. [more]
Center NameCHIBA_U