Study Detail

TitleFunctionally distinct Gata3/Chd4 complexes coordinately establish Th2 cell identity.
Study TypeEpigenetics
Abstract Gata3 is a GATA family transcription factor that controls differentiation of naïve CD4 T cells into T helper (Th) 2 cells. However, it is unknown how Gata3 simultaneously activates Th2-specific genes while repressing those of other Th lineages. Here we show that Chd4 (chromodomain helicase DNA-bindi .. [more]
Description Mouse naïve CD4 T cells were stimulated under Th1 or Th2 conditions for 3 days and 5 days, then ChIP-seq for Chd4 and TSS-seq were performed.
Center NameUT-MGS