Study Detail

TitleH3K9me3 prevents maternal Xist activation to establish imprinted X chromosome inactivation in mouse preimplantation phase embryos
Study TypeEpigenetics
Abstract Maintaining a single active X chromosome is essential for the development of female mammals. In pre-implantation embryos of mice, the expression of Xist triggers X chromosome inactivation (XCI) in cis, is limited to the paternal allele and maternal Xist (Xm-Xist) is repressed. Here, we demonstrate f .. [more]
Center NameNCCHD