| Title | Genomic analysis in Xenopus limb bud regeneration |
| Study Type | Other |
| Abstract |
To reveal cellular properties of regenerating limb bud cells in Xenopus limb bud regeneration, we analyzed genome-wide histone modifications. The trimethylation of histone H3 at lysine 4 (H3K4me3) is closely related to an open chromatin structure that allows transcription factors access to genes, wh .. [more]ereas the trimethylation of histone H3 at lysine 27 (H3K27me3) is related to a closed chromatin state that blocks transcription-factor access. We compared these two modification profiles by high-throughput sequencing of samples prepared from the intact limb bud and the regenerative blastema by chromatin immunoprecipitation. [less]
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| Description |
To reveal cellular properties of regenerating limb bud cells in Xenopus limb bud regeneration, we analyzed genome-wide histone modifications. The trimethylation of histone H3 at lysine 4 (H3K4me3) is closely related to an open chromatin structure that allows transcription factors access to genes, wh .. [more]ereas the trimethylation of histone H3 at lysine 27 (H3K27me3) is related to a closed chromatin state that blocks transcription-factor access. We compared these two modification profiles by high-throughput sequencing of samples prepared from the intact limb bud and the regenerative blastema by chromatin immunoprecipitation. [less]
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| Center Name | TOHOKU |
FTP
