Study Detail

TitleEzh2 loss cooperates with an active JAK2 mutant in the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition
Study TypeOther
Abstract EZH2 is a component of polycomb repressive complex (PRC) 2 and functions as an H3K27 methyltransferase. Loss-of-function mutations in EZH2 are associated with worse outcome in patients with myeloproliferative neoplasms (MPN), particularly with primary myelofibrosis (PMF). To understand how EZH2 in .. [more]
Description EZH2 is a component of polycomb repressive complex (PRC) 2 and functions as an H3K27 methyltransferase. Loss-of-function mutations in EZH2 are associated with worse outcome in patients with myeloproliferative neoplasms (MPN), particularly with primary myelofibrosis (PMF). To understand how EZH2 in .. [more]
Center NameCHIBA_U