Study Detail

TitleH3K9 methyltransferase Setdb1 is a critical regulator of hematopoietic stem and progenitor cells.
Study TypeOther
Abstract Setdb1, an H3K9 histone methyltransferase, plays an essential role in silencing of endogenous retroviral elements (ERVs) in early embryo and embryonic stem cells (ESCs). However, its role in somatic stem cells remains unclear. We show that deletion of Setdb1 causes rapid depletion of hematopoietic s .. [more]
Description Setdb1, an H3K9 histone methyltransferase, plays an essential role in silencing of endogenous retroviral elements (ERVs) in early embryo and embryonic stem cells (ESCs). However, its role in somatic stem cells remains unclear. We show that deletion of Setdb1 causes rapid depletion of hematopoietic s .. [more]
Center NameCHIBA_U