Study Detail

TitleDual inhibition of EZH2 and EZH1 sensitizes PRC2-dependent tumors to proteasome inhibition
Study TypeOther
Abstract Histone methyltransferases EZH2 and EZH1, the catalytic components of polycomb repressive complex 2 (PRC2), trigger H3K27me3 to repress the transcription of target genes and are implicated in tumorigenesis. Here, we demonstrate PRC2-dependency in multiple myeloma (MM) cells using EZH2 knockdown and .. [more]
Description Histone methyltransferases EZH2 and EZH1, the catalytic components of polycomb repressive complex 2 (PRC2), trigger H3K27me3 to repress the transcription of target genes and are implicated in tumorigenesis. Here, we demonstrate PRC2-dependency in multiple myeloma (MM) cells using EZH2 knockdown and .. [more]
Center NameCHIBA_U