Study Detail

TitlePhf6 restricts the self-renewal of hematopoietic stem cells via regulation of Nr4a1 expression
Study TypeOther
Abstract Recurrent inactivating mutations have been identified in various hematological malignancies in the X-linked PHF6 gene. However, it is currently unknown how PHF6 regulates normal hematopoiesis and how inactivation of PHF6 contributes to leukemogenesis. To get insight into this, we generated a mouse l .. [more]
Description Recurrent inactivating mutations have been identified in various hematological malignancies in the X-linked PHF6 gene. However, it is currently unknown how PHF6 regulates normal hematopoiesis and how inactivation of PHF6 contributes to leukemogenesis. To get insight into this, we generated a mouse l .. [more]
Center NameCHIBA_U