Study Detail

TitleChimeric mice with humanized livers demonstrate human-specific hepatotoxicity caused by a therapeutic antibody against TRAIL-receptor 2/death receptor 5
Study TypeOther
Abstract The activation of tumor necrosis factor (TNF)-related apoptosis-inducing ligand receptor 2 (TRAIL-R2)/death receptor 5 (DR5) induces apoptosis in various tumor cells but not in normal human cells. Since some therapeutic antibodies targeting TRAIL-R2 have demonstrated severe hepatotoxicity in clinica .. [more]
Description The activation of tumor necrosis factor (TNF)-related apoptosis-inducing ligand receptor 2 (TRAIL-R2)/death receptor 5 (DR5) induces apoptosis in various tumor cells but not in normal human cells. Since some therapeutic antibodies targeting TRAIL-R2 have demonstrated severe hepatotoxicity in clinica .. [more]
Center NameKHK