Study Detail

TitleThe polycomb protein Bmi1 restricts adipogenic differentiation of mesenchymal stromal cells to maintain the integrity of hematopoietic stem cell niche.
Study TypeOther
Abstract The polycomb group protein Bmi1 maintains hematopoietic stem cell (HSC) functions. We previously reported that Bmi1-deficient mice showed a progressive fatty change of bone marrow (BM). A large portion of HSCs reside in perivascular niche created partly by endothelial cells and leptin receptor+ (Lep .. [more]
Description The polycomb group protein Bmi1 maintains hematopoietic stem cell (HSC) functions. We previously reported that Bmi1-deficient mice showed a progressive fatty change of bone marrow (BM). A large portion of HSCs reside in perivascular niche created partly by endothelial cells and leptin receptor+ (Lep .. [more]
Center NameCHIBA_U