Study Detail

TitleLineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the development of blastic plasmacytoid dendritic cell neoplasm
Study TypeOther
Abstract Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive subtype of acute myeloid leukemia, the cell of origin of which is considered to be precursors of plasmacytoid dendritic cells (pDCs). BPDCN cells show high frequencies of mutations in the major tumor suppressors of TET2 and TP53; .. [more]
Description Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive subtype of acute myeloid leukemia, the cell of origin of which is considered to be precursors of plasmacytoid dendritic cells (pDCs). BPDCN cells show high frequencies of mutations in the major tumor suppressors of TET2 and TP53; .. [more]
Center NameIRCMS