Study Detail

TitleKDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T- cell leukemogenesis
Study TypeOther
Abstract KDM2B together with RING1B, PCGF1, and BCOR or BCORL1 comprise polycomb repressive complex 1.1 (PRC1.1), a non-canonical PRC1 that catalyzes H2AK119ub1. It binds to non-methylated CpG islands through its zinc finger-CxxC (ZF-CxxC) DNA binding domain and recruits the complex to target gene loci. Rece .. [more]
Description KDM2B together with RING1B, PCGF1, and BCOR or BCORL1 comprise polycomb repressive complex 1.1 (PRC1.1), a non-canonical PRC1 that catalyzes H2AK119ub1. It binds to non-methylated CpG islands through its zinc finger-CxxC (ZF-CxxC) DNA binding domain and recruits the complex to target gene loci. Rece .. [more]
Center NameUT_IMS