Study Detail

Study TypeOther
Abstract The JAK2 V617F mutation is found in most patients with a myeloproliferative neoplasm (MPN) including polycytheamia vera (PV), essential thrombocytheamia (ET) and idiopathic myelofibrosis (IMF). It is unclear how a single point mutation in JAK2 is associated with different diseases. We therefore gen .. [more]
Description Exome sequencing of the polycytheamia vera (PV)-like or bone marrow fibrotic transformation mice. We have established a conditional JAK2 V617F mouse line that develops essential thrombocytheamia with approximately 10% PV-like or bone marrow fibrotic transformation. In this experiment we will sequenc .. [more]
Center NameSC