Study Detail

TitleTEL_AML1_mouse_backcross
Study TypeWhole Genome Sequencing
Abstract In this experiment we are using sequencing to identify a modifier locus associated with embryonic lethality in mice carrying a Tel-AML1 transgene. We find that on a 129S5 background mice carrying the Tel-AML1 transgene are viable but the transgene is lethal on a C57BL/6J background. We generated an .. [more]
Description The t(12;21) translocation which generates the ETV6-RUNX1 (TEL-AML1) fusion gene, is the most common chromosomal rearrangement in childhood cancer and is exclusively associated with B-cell precursor acute lymphoblastic leukemia (BCP-ALL). The translocation arises in utero and is necessary but insuff .. [more]
Center NameSC