Study Detail

TitleInterleukin-7 abrogates the immunosuppressive function of human double-negative T cells by activating Akt/mTOR signaling
Study TypeOther
Abstract Recently, a novel subset of TCRaß+ CD4- CD8- double-negative (DN) T cells has been described to suppress immune responses in both mice and humans. Moreover, in murine models infusion and/or activation of DN T cells specifically suppressed alloreactive T cells and prevented development of Graft-versu .. [more]
Description Recently, a novel subset of TCRaß+ CD4- CD8- double-negative (DN) T cells has been described to suppress immune responses in both mice and humans. Moreover, in murine models infusion and/or activation of DN T cells specifically suppressed alloreactive T cells and prevented development of Graft-versu .. [more]
Center NameDepartment of Internal Medicine 5 - Hematology/Oncology