Study Detail

TitletRNA processing defects induce replication stress and Chk2-dependent disruption of piRNA transcription
Study TypeOther
Abstract RNase P is a conserved endonuclease that processes the 5' trailer of tRNA precursors. We have isolated mutations in Rpp30, a subunit of RNase P, and find that these induce complete sterility in Drosophila females. Here we show that sterility is not due to a shortage of mature tRNAs, but that atrophi .. [more]
Description RNase P is a conserved endonuclease that processes the 5' trailer of tRNA precursors. We have isolated mutations in Rpp30, a subunit of RNase P, and find that these induce complete sterility in Drosophila females. Here we show that sterility is not due to a shortage of mature tRNAs, but that atrophi .. [more]
Center NameCentre National de la Recherche Scientifique