Study Detail

TitleA non-active site mutation in lanosterol 14a demethylase leads to loss of ergosterol biosynthesis and underlies Amphotericin B resistance in Leishmania mexicana
Study TypeOther
Abstract Amphotericin B has emerged as the therapy of choice for use against the Leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being promoted in a campaign to bring the leishmaniases under control. Understanding the risks and mechanisms of resistance is ther .. [more]
Description Amphotericin B has emerged as the therapy of choice for use against the Leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being promoted in a campaign to bring the leishmaniases under control. Understanding the risks and mechanisms of resistance is ther .. [more]
Center NameWellcome Trust Centre for Molecular Parasitology, University of Glasgow , UK