Study Detail

TitleQuantification of in vivo progenitor mutation accrual by detection of ultra-rare mutations in minute amounts of DNA
Study TypeOther
Abstract Assaying in vivo accrual of DNA damage and mutations by stem cells would further our understanding of aging and carcinogenesis. Two main hurdles hamper such assays. First, in vivo mutation rates are orders of magnitude lower than raw error rates of current sequencing procedures. Second, stem cells a .. [more]
Description Assaying in vivo accrual of DNA damage and mutations by stem cells would further our understanding of aging and carcinogenesis. Two main hurdles hamper such assays. First, in vivo mutation rates are orders of magnitude lower than raw error rates of current sequencing procedures. Second, stem cells a .. [more]
Center NameUC IRVINE