Study Detail

TitleThis study shows that S. aureus is more versatile than recently concluded. First, mutants selected on the FabI inhibitor triclosan are about 100-fold more frequent when fatty acids are available. A novel FASII bypass target is identified as FabD, a malonyl CoA-acyl carrier protein transacylase.
Study TypeOther
Abstract Antimicrobials targeting the fatty acid synthesis pathway (FASII) may be bypassed by numerous pathogens that incorporate host fatty acids. This activity would greatly restrict use of anti-FASII drugs. However, the status of Staphylococcus aureus is controversial, based on suggestions that major self .. [more]
Description Antimicrobials targeting the fatty acid synthesis pathway (FASII) may be bypassed by numerous pathogens that incorporate host fatty acids. This activity would greatly restrict use of anti-FASII drugs. However, the status of Staphylococcus aureus is controversial, based on suggestions that major self .. [more]
Center NameINRA