Study Detail

TitleTrim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity
Study TypeOther
Abstract More than one-half billion people are obese, and despite progress in genetic research, much of the high heritability of obesity remains enigmatic. Here, we identify a Trim28-dependent network capable of triggering obesity in a non-Mendelian, "on/off" manner. Trim28 +/D9 mutant mice exhibit a bi-moda .. [more]
Description More than one-half billion people are obese, and despite progress in genetic research, much of the high heritability of obesity remains enigmatic. Here, we identify a Trim28-dependent network capable of triggering obesity in a non-Mendelian, "on/off" manner. Trim28 +/D9 mutant mice exhibit a bi-moda .. [more]
Center NameMAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS