Study Detail

TitleHomeostatic Control of Innate Immune Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis
Study TypeOther
Abstract Mutations in the autophagy gene EPG5 are linked to the multisystem human disease Vici syndrome, characterized by neurologic, muscular, and pulmonary abnormalities. We found that Epg5-/- mice exhibited elevated baseline innate immune cellular and cytokine-based lung inflammation and were resistant to .. [more]
Description Mutations in the autophagy gene EPG5 are linked to the multisystem human disease Vici syndrome, characterized by neurologic, muscular, and pulmonary abnormalities. We found that Epg5-/- mice exhibited elevated baseline innate immune cellular and cytokine-based lung inflammation and were resistant to .. [more]
Center NameWASHINGTON UNIVERSITY SCHOOL OF MEDICINE