Title | Reduced representation of bisulfite sequencing (RRBS) of murine T-cell acute lymphoblastic leukemia (T-ALL) cells to investigate DNA methylation profiling of lymphocyte deficient for Tet2 and mutated for DNMT3A |
Study Type | Other |
Abstract | T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive proliferation of T-lymphocytes usually associated with oncogenic activation of NOTCH1 signaling. Using a bone marrow transplantation approach, we have modeled murine CD4+ CD8+ T-ALL by overexpressing DNMT3A R882H in Tet2-/- multipotent pro .. [more]genitors. T-ALL derived from NOTCH1 L1601PdelP Tet2-/-, NOTCH1 L1601PdelP Tet2+/+ or TCL1A progenitors were used for comparison, as well as normal Tet2+/+ and Tet2-/- CD4+ CD8+ double positive (DP) thymocytes. [less] |
Description | T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive proliferation of T-lymphocytes usually associated with oncogenic activation of NOTCH1 signaling. Using a bone marrow transplantation approach, we have modeled murine CD4+ CD8+ T-ALL by overexpressing DNMT3A R882H in Tet2-/- multipotent pro .. [more]genitors. T-ALL derived from NOTCH1 L1601PdelP Tet2-/-, NOTCH1 L1601PdelP Tet2+/+ or TCL1A progenitors were used for comparison, as well as normal Tet2+/+ and Tet2-/- CD4+ CD8+ double positive (DP) thymocytes. [less] |
Center Name | UMR 1170 INSERM Institut Gustave Roussy |
Url Link | E-MTAB-4159 in ArrayExpress |
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Submission | ERA549946 |
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Experiment | ERX1270241 |
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ERX1270242 |
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ERX1270243 |
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ERX1270244 |
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ERX1270245 |
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ERX1270246 |
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ERX1270247 |
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ERX1270248 |
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ERX1270249 |
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ERX1270250 |
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Sample | ERS1026464 | ||
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