Study Detail

TitleIn this study we tested the hypothesis that generalized codon ambiguity could be beneficial to evolution of resistance against amphotericin B. For this, we have evolved C. albicans strains that incorporate serine at CTA , CTC, CTT (Leucine), ATC (Isoleucine), GCC (Alanine), GGA (Glycine), AAG (Lysine), ACC (Threonine) and TAC (Tyrosine) codons in the presence amphotericin B and characterized them at the genome level. We identified a number of genomic features and key genes that shed new light onto how chimeric tRNAs affects acquisition of resistance to amphotericin B.
Study TypeOther
Abstract Translational errors that occur at high rates influence organism viability decreasing is fitness, however these translational errors can increase proteomic diversity providing an advantageous source of phenotypic variability. Previous studies linked Candida albicans CUG codon ambiguous translation t .. [more]
Description Translational errors that occur at high rates influence organism viability decreasing is fitness, however these translational errors can increase proteomic diversity providing an advantageous source of phenotypic variability. Previous studies linked Candida albicans CUG codon ambiguous translation t .. [more]
Center NameiBiMED - Institute of Biomedicine