Study Detail

TitleDual readout of two histone modifications at the same time with synthetic recombinant proteins reveals H3K36me3-H3K9me3 bivalency at weakly transcribed genes
Study TypeWhole Genome Sequencing
Abstract In this proof-of-principle approach we have successfully applied a recombinant heterotypic histone modification interacting domain (HiMID) against H3K9me3 and H3K36me2/3 by using AND logic. We discovered that this new bivalent state is associated with the bodies of weakly transcribed genes and enhan .. [more]
Description In this proof-of-principle approach we have successfully applied a recombinant heterotypic histone modification interacting domain (HiMID) against H3K9me3 and H3K36me2/3 by using AND logic. We discovered that this new bivalent state is associated with the bodies of weakly transcribed genes and enhan .. [more]
Center NameInstitute of Biochemistry, University of Stuttgart