Study Detail

TitleWe use single-cell derived xenografts to study the expansion of tumours in vivo and performed whole-exome sequencing to determine the underlying evolutionary dynamics.
Study TypeOther
Abstract Next-generation sequencing (NGS) has been used to infer tumor ancestries and mutational timing. However, the inference of subclonal architecture from NGS data without reference to the dynamics of tumor growth may lead to an erroneous interpretation of clonal relationships. Here we analyze multi-regi .. [more]
Description Next-generation sequencing (NGS) has been used to infer tumor ancestries and mutational timing. However, the inference of subclonal architecture from NGS data without reference to the dynamics of tumor growth may lead to an erroneous interpretation of clonal relationships. Here we analyze multi-regi .. [more]
Center NameINSTITUTE OF CANCER RESEARCH