Study Detail

TitleGenomic aberrations in crizotinib resistant lung adenocarcinoma samples by transcriptome sequencing
Study TypeOther
Abstract ALK-break positive non-small cell lung cancer (NSCLC) patients initially respond to crizotinib, but resistance occurs inevitably. In this study we aimed to identify fusion genes in crizotinib resistant tumor samples. Re-biopsies of three patients were subjected to paired-end RNA sequencing to identi .. [more]
Description ALK-break positive non-small cell lung cancer (NSCLC) patients initially respond to crizotinib, but resistance occurs inevitably. In this study we aimed to identify fusion genes in crizotinib resistant tumor samples. Re-biopsies of three patients were subjected to paired-end RNA sequencing to identi .. [more]
Center NameUniversity Medical Center Groningen, University of Groningen