Study Detail

TitleQuantifying epigenotype variations between mouse B and CD4+ T lymphocytes
Study TypeEpigenetics
Abstract Epigenetic mechanisms are involved in the acquisition and maintenance of cell type-specific gene expression programmes during development and differentiation. In order to identify and better classify abnormalities in the epigenome that are linked to pathological conditions, the epigenome of normal c .. [more]
Description This study aims at performing a genome wide comparative epigenomic and transcriptomic analysis of normal ex-vivo primary populations of lymphocytes of the adaptive immune system. Stocks of adult C57BL/6J mice are used for the isolation of pure and synchronous populations of resting B and naïve CD4+ .. [more]
Center NameThe Wellcome Trust Sanger Institute