Study Detail

TitleIntrinsic transcriptional heterogeneity in B cells controls early class switching to IgE
Study TypeTranscriptome Analysis
Abstract Non-coding transcripts originating upstream of the immunoglobulin constant region (I-transcripts) are required to direct activation-induced deaminase to initiate class switching in B cells. Differential regulation of Ie and I?1 transcription in response to interleukin-4 (IL-4), hence class switchin .. [more]
Description Non-coding transcripts originating upstream of the immunoglobulin constant region (I-transcripts) are required to direct activation-induced deaminase to initiate class switching in B cells. Differential regulation of Ie and I?1 transcription in response to interleukin-4 (IL-4), hence class switchin .. [more]
Center NameWELLCOME TRUST SANGER INSTITUTE