Study Detail

TitleTrypanosoma brucei genome-wide RNAi library screen of methotrexate.
Study TypeOther
Abstract The aim of this study was to identify and characterise mechanisms of resistance to antifolate drugs in African trypanosomes. A genome-wide RNAi library screen was undertaken in bloodstream form Trypanosoma brucei exposed to the antifolate methotrexate. RNAi knockdown in conjunction with drug suscept .. [more]
Description The aim of this study was to identify and characterise mechanisms of resistance to antifolate drugs in African trypanosomes. A genome-wide RNAi library screen was undertaken in bloodstream form Trypanosoma brucei exposed to the antifolate methotrexate. RNAi knockdown in conjunction with drug suscept .. [more]
Center NameUniversity of Dundee