Study Detail

TitleWe generated a mouse model that allows conditional knock-out of the NADPH-P450 oxidoreductase (Por) gene, which is the only electron donor for all murine cytochromes and embryonic-lethal when deleted1. We introduced additional deletions in the conditional Porc/c mouse to generate a PIRF (Porc/c /Il2rg-/- /Rag2-/-/Fah-/-) strain. These data compare expression profiles in the resulting tissues.
Study TypeOther
Abstract Only one out of ten drugs in development gets approved for clinical use. The majority fails during clinical trials because they are ineffective or toxic in humans; this in turn is because animal models often fail to predict human xenobiotic metabolism. Human liver chimeric mice have been a step forw .. [more]
Description Only one out of ten drugs in development gets approved for clinical use. The majority fails during clinical trials because they are ineffective or toxic in humans; this in turn is because animal models often fail to predict human xenobiotic metabolism. Human liver chimeric mice have been a step forw .. [more]
Center NameBAYLOR COLLEGE OF ME