Study Detail

TitleRNA-Seq in liver of Tc1 mice carrying human chromosome 21 passaged through either the female or male germline
Study TypeTranscriptome Analysis
Abstract This study aims to investigate whether the passage of human chromosome 21 through the mouse male germline results in changes in the transcriptional deployment of the exogenous chromosome in the offspring generation. We used the Tc1 mouse model that stably carries almost an entire copy of human chrom .. [more]
Description This study aims to investigate whether the passage of human chromosome 21 through the mouse male germline results in changes in the transcriptional deployment of the exogenous chromosome in the offspring generation. We used the Tc1 mouse model that stably carries almost an entire copy of human chrom .. [more]
Center NameCancer Research UK Cambridge Institute University of Cambridge