Title | Genomic insight into mechanisms of reversion of antibiotic resistance in multidrug resistant Mycobacterium tuberculosis induced by the nanomolecular iodine-containing complex FS-1 |
Study Type | Other |
Abstract |
New antituberculosis drug FS-1 inducing drug resistance reversion was used in this work in combination with anti-mycobacterial antibiotics in an experiment on 105 laboratory guinea pigs infected with the multidrug resistant (MDR) strain M. tuberculosis (Mtb) SCAID 187.0 (CP012506). One group of anim .. [more]als was not infected and used as a negative control. Genetic changes in the Mtb population were analysed during the trial by sequencing of Mtb isolates from four groups of animals: group 2 (positive control, not treated), group 3 (treated solely with antibiotics), group 4 (antibiotics + 2.5 mg/kg FS-1) and group 5 (antibiotics + 4.0 mg/kg FS-1). The following antibiotics were used in this study: pyrazinamide (per os 100 mg/kg), cycloserine (per os 20.0 mg/kg), prothionamide (per os 20.0 mg/kg), capreomycin (intramuscular 20.0 mg/kg) and amikacin (intramuscular 50.0 mg/kg). The therapy with the antibiotics lasted for 60 days. [less]
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Description |
New antituberculosis drug FS-1 inducing drug resistance reversion was used in this work in combination with anti-mycobacterial antibiotics in an experiment on 105 laboratory guinea pigs infected with the multidrug resistant (MDR) strain M. tuberculosis (Mtb) SCAID 187.0 (CP012506). One group of anim .. [more]als was not infected and used as a negative control. Genetic changes in the Mtb population were analysed during the trial by sequencing of Mtb isolates from four groups of animals: group 2 (positive control, not treated), group 3 (treated solely with antibiotics), group 4 (antibiotics + 2.5 mg/kg FS-1) and group 5 (antibiotics + 4.0 mg/kg FS-1). The following antibiotics were used in this study: pyrazinamide (per os 100 mg/kg), cycloserine (per os 20.0 mg/kg), prothionamide (per os 20.0 mg/kg), capreomycin (intramuscular 20.0 mg/kg) and amikacin (intramuscular 50.0 mg/kg). The therapy with the antibiotics lasted for 60 days. [less]
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Center Name | SCAID |