ERP016477
Study Detail
| Title | Genomic insight into mechanisms of reversion of antibiotic resistance in multidrug resistant Mycobacterium tuberculosis induced by the nanomolecular iodine-containing complex FS-1 |
| Study Type | Other |
| Abstract | New antituberculosis drug FS-1 inducing drug resistance reversion was used in this work in combination with anti-mycobacterial antibiotics in an experiment on 105 laboratory guinea pigs infected with the multidrug resistant (MDR) strain M. tuberculosis (Mtb) SCAID 187.0 (CP012506). One group of anim .. [more]als was not infected and used as a negative control. Genetic changes in the Mtb population were analysed during the trial by sequencing of Mtb isolates from four groups of animals: group 2 (positive control, not treated), group 3 (treated solely with antibiotics), group 4 (antibiotics + 2.5 mg/kg FS-1) and group 5 (antibiotics + 4.0 mg/kg FS-1). The following antibiotics were used in this study: pyrazinamide (per os 100 mg/kg), cycloserine (per os 20.0 mg/kg), prothionamide (per os 20.0 mg/kg), capreomycin (intramuscular 20.0 mg/kg) and amikacin (intramuscular 50.0 mg/kg). The therapy with the antibiotics lasted for 60 days. [less] |
| Description | New antituberculosis drug FS-1 inducing drug resistance reversion was used in this work in combination with anti-mycobacterial antibiotics in an experiment on 105 laboratory guinea pigs infected with the multidrug resistant (MDR) strain M. tuberculosis (Mtb) SCAID 187.0 (CP012506). One group of anim .. [more]als was not infected and used as a negative control. Genetic changes in the Mtb population were analysed during the trial by sequencing of Mtb isolates from four groups of animals: group 2 (positive control, not treated), group 3 (treated solely with antibiotics), group 4 (antibiotics + 2.5 mg/kg FS-1) and group 5 (antibiotics + 4.0 mg/kg FS-1). The following antibiotics were used in this study: pyrazinamide (per os 100 mg/kg), cycloserine (per os 20.0 mg/kg), prothionamide (per os 20.0 mg/kg), capreomycin (intramuscular 20.0 mg/kg) and amikacin (intramuscular 50.0 mg/kg). The therapy with the antibiotics lasted for 60 days. [less] |
| Center Name | SCAID |
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Submission | ERA676212 |
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Experiment | ERX1615196 |
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SRA
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| ERX1615197 |
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| ERX1615198 |
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| ERX1615199 |
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| ERX1615200 |
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| ERX1615201 |
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| ERX1615202 |
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| ERX1615203 |
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| ERX1615204 |
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| ERX1615205 |
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| ERX1615206 |
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Sample | ERS1250344 | ||
| ERS1250345 | ||||
| ERS1250346 | ||||
| ERS1250347 | ||||
| ERS1250348 | ||||
| ERS1250349 | ||||
| ERS1250350 | ||||
| ERS1250351 | ||||
| ERS1250352 | ||||
| ERS1250353 | ||||
| ERS1250354 |