Study Detail

TitleThymic epithelial cells require p53 to support their role in T-cell development and tolerance induction.
Study TypeOther
Abstract Thymic epithelial cells (TECs) constitute crucial microenvironments for T-cell development and self-tolerance. Beyond its recognized tumor suppressive function, p53 regulates the differentiation of multiple cell lineages. To study the cell-autonomous role of p53 in thymic epithelial homeostasis, we .. [more]
Description Thymic epithelial cells (TECs) constitute crucial microenvironments for T-cell development and self-tolerance. Beyond its recognized tumor suppressive function, p53 regulates the differentiation of multiple cell lineages. To study the cell-autonomous role of p53 in thymic epithelial homeostasis, we .. [more]
Center NameEuropean Molecular Biology Laboratory