Study Detail

TitleShallow whole genome sequencing of biopsies from retinoblastoma tumors in chimeric murine knockout double mice (pRb-p130 and pRb-p107 knockouts) to identify secondary alterations that drive oncogenesis.
Study TypeOther
Abstract Several murine retinoblastoma models have been generated by deleting the genes encoding for retinoblastoma susceptibility protein pRb and one of its family members p107 or p130. In Rb-/-p107-/- retinoblastomas, somatic copy number alterations (SCNAs) like Mdm2 amplification or Cdkn2a deletion target .. [more]
Description Several murine retinoblastoma models have been generated by deleting the genes encoding for retinoblastoma susceptibility protein pRb and one of its family members p107 or p130. In Rb-/-p107-/- retinoblastomas, somatic copy number alterations (SCNAs) like Mdm2 amplification or Cdkn2a deletion target .. [more]
Center NameVU UNIVERSITY MEDICAL CENTER AMSTERDAM THE NETHERL