Study Detail

TitleCentrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals
Study TypeOther
Abstract Centrosome amplification is a common feature of human tumors, but whether this is a cause or a consequence of human cancer remains unclear. Here, we report the creation of a mouse model in which centrosome number can be persistently increased in the absence of additional genetic defects. We show tha .. [more]
Description Centrosome amplification is a common feature of human tumors, but whether this is a cause or a consequence of human cancer remains unclear. Here, we report the creation of a mouse model in which centrosome number can be persistently increased in the absence of additional genetic defects. We show tha .. [more]
Center NameLaboratory of Translational Genetics, Vesalius Research Center, VIB, Leuven, Belgium. Laboratory of Translational Genetics, Department of Oncology, KU Leuven, Belgium.