Study Detail

TitleOverexpression of PGC-1a in aging muscle enhances a large sub-set of young-like gene expression patterns
Study TypeOther
Abstract PGC-1a is a transcriptional co-activator known as the master regulator of mitochondrial biogenesis. Its control of gene expression has been suggested to play a role in neurodegenerative diseases and the aging process. We have aged mice overexpressing PGC-1a in skeletal muscle to determine whether li .. [more]
Description PGC-1a is a transcriptional co-activator known as the master regulator of mitochondrial biogenesis. Its control of gene expression has been suggested to play a role in neurodegenerative diseases and the aging process. We have aged mice overexpressing PGC-1a in skeletal muscle to determine whether li .. [more]
Center NameUNESP - Univ Estadual Paulista, Institute of biosciences of Botucatu