ERP017164
Study Detail
| Title | A single therapeutic early-in-life antibiotic course alters host immunologic development |
| Study Type | Transcriptome Analysis |
| Abstract | Broad-spectrum antibiotics are frequently prescribed to children. The period of early-childhood represents a time where the developing microbiota may be more sensitive to environmental perturbations, which thus might have long-lasting host consequences. We hypothesized that even a single early-life .. [more]broad-spectrum antibiotic course at a therapeutic dose (PAT) leads to durable alterations in both the gut microbiota and host immunity. In C57BL/6 mice, a single early-life tylosin (macrolide) course markedly altered the intestinal microbiome, and affected specific intestinal T-cell populations and secretory IgA expression, but PAT-exposed adult dams had minimal immunologic alterations. No immunological effects were detected in PAT-exposed germ-free animals; indicating that microbiota are required for the observed activities. Together these results indicate the impact of a single therapeutic early-life antibiotic course altering the microbiota and modulating host immune phenotypes that persist long after exposure has ceased. [less] |
| Description | Broad-spectrum antibiotics are frequently prescribed to children. The period of early-childhood represents a time where the developing microbiota may be more sensitive to environmental perturbations, which thus might have long-lasting host consequences. We hypothesized that even a single early-life .. [more]broad-spectrum antibiotic course at a therapeutic dose (PAT) leads to durable alterations in both the gut microbiota and host immunity. In C57BL/6 mice, a single early-life tylosin (macrolide) course markedly altered the intestinal microbiome, and affected specific intestinal T-cell populations and secretory IgA expression, but PAT-exposed adult dams had minimal immunologic alterations. No immunological effects were detected in PAT-exposed germ-free animals; indicating that microbiota are required for the observed activities. Together these results indicate the impact of a single therapeutic early-life antibiotic course altering the microbiota and modulating host immune phenotypes that persist long after exposure has ceased. [less] |
| Center Name | NEW YORK UNIVERSITY SCHOOL OF MEDICINE |
SRA Links
| Url Link | E-MTAB-5101 in ArrayExpress |
Navigation
|
Submission | ERA707293 |
 FTP
|
|
|
Experiment | ERX1708422 |
FASTQ
|
SRA
|
| ERX1708423 |
FASTQ
|
SRA
|
||
| ERX1708424 |
FASTQ
|
SRA
|
||
| ERX1708425 |
FASTQ
|
SRA
|
||
| ERX1708426 |
FASTQ
|
SRA
|
||
| ERX1708427 |
FASTQ
|
SRA
|
||
| ERX1708428 |
FASTQ
|
SRA
|
||
| ERX1708429 |
FASTQ
|
SRA
|
||
| ERX1708430 |
FASTQ
|
SRA
|
||
| ERX1708431 |
FASTQ
|
SRA
|
||
| ERX1708432 |
FASTQ
|
SRA
|
||
| ERX1708433 |
FASTQ
|
SRA
|
||
| ERX1708434 |
FASTQ
|
SRA
|
||
| ERX1708435 |
FASTQ
|
SRA
|
||
| ERX1708436 |
FASTQ
|
SRA
|
||
| ERX1708437 |
FASTQ
|
SRA
|
||
|
|
Sample | ERS1355138 | ||
| ERS1355139 | ||||
| ERS1355140 | ||||
| ERS1355141 | ||||
| ERS1355142 | ||||
| ERS1355143 | ||||
| ERS1355144 | ||||
| ERS1355145 | ||||
| ERS1355146 | ||||
| ERS1355147 | ||||
| ERS1355148 | ||||
| ERS1355149 | ||||
| ERS1355150 | ||||
| ERS1355151 | ||||
| ERS1355152 | ||||
| ERS1355153 |