Study Detail

TitleEpigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts
Study TypeOther
Abstract Haploinsufficiency for the erythroid-specific transcription factor KLF1 is associated with hereditary persistence of fetal hemoglobin (HPFH). Increased HbF ameliorates the symptoms of ?-hemoglobinopathies and downregulation of KLF1 activity has been proposed as a potential therapeutic strategy. Howe .. [more]
Description Haploinsufficiency for the erythroid-specific transcription factor KLF1 is associated with hereditary persistence of fetal hemoglobin (HPFH). Increased HbF ameliorates the symptoms of ?-hemoglobinopathies and downregulation of KLF1 activity has been proposed as a potential therapeutic strategy. Howe .. [more]
Center NameERASMUS MC