Title | ATAC-seq of primary mammalian aortic endothelial cells before and after TNFa stimulation |
Study Type | Other |
Abstract | To identify conserved TNFa-induced changes in chromatin-accessibility in mammals, we performed ATAC-seq in primary vascular endothelial cells (ECs) isolated from the aortas of human (HAEC), mouse (MAEC) and cow (BAEC), before and after TNFa. We overlay our data with multi-species NF-?B binding data .. [more]and identify multiple modes of NF-?B-chromatin interactions that are conserved during mammalian TNFa response. Our cross-species approach identifies conserved changes in chromatin-accessibility at NF-?B binding sites that are disease-relevant and essential during mammalian acute inflammation. [less] |
Description | To identify conserved TNFa-induced changes in chromatin-accessibility in mammals, we performed ATAC-seq in primary vascular endothelial cells (ECs) isolated from the aortas of human (HAEC), mouse (MAEC) and cow (BAEC), before and after TNFa. We overlay our data with multi-species NF-?B binding data .. [more]and identify multiple modes of NF-?B-chromatin interactions that are conserved during mammalian TNFa response. Our cross-species approach identifies conserved changes in chromatin-accessibility at NF-?B binding sites that are disease-relevant and essential during mammalian acute inflammation. [less] |
Center Name | The Hospital for Sick Children, Genetics and Genome Biology University of Toronto, Department of Molecular Genetics |
Url Link | E-MTAB-7878 in ArrayExpress |
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Submission | ERA1837514 |
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Experiment | ERX3308138 |
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Sample | ERS3370477 | ||
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