Study Detail

TitleReplisome stability at defective DNA replication forks is independent of S-phase checkpoint kinases
Study TypeWhole Genome Sequencing
Abstract The S-phase checkpoint pathway preserves genome stability by protecting defective DNA replication forks, but the underlying mechanisms are still understood poorly. Previous work with budding yeast indicated that the checkpoint kinases Mec1 and Rad53 prevent collapse of the replisome when nucleotide .. [more]
Description ChIP-seq analyses of replisome proteins in the absence or presence of checkpoint cascade.
Center NameResearch Center for Epigenetic Disease, The Univer