Study Detail

TitleThe DNA-binding protein CTCF limits proximal V? recombination and restricts ? enhancer interactions to the immunoglobulin ? light chain locus.
Study TypeEpigenetics
Abstract Regulation of immunoglobulin (Ig) V(D)J gene rearrangement is dependent on higher-order chromatin organization. Here, we studied the in vivo function of the DNA-binding zinc-finger protein CTCF, which regulates interactions between enhancers and promoters. By conditional deletion of the Ctcf gene in .. [more]
Center NameBergen Center for Computational Science