Study Detail

TitleGenome-wide structure and organization of eukaryotic pre-initiation complexes
Study TypeWhole Genome Sequencing
Abstract Transcription and regulation of genes originate from transcription pre-initiation complexes (PICs). Their structural and positional organization across eukaryotic genomes is unknown. Here we applied lambda exonuclease to chromatin immunoprecipitates (termed ChIP-exo) to examine the precise location .. [more]
Description Ultra-high-resolution mapping of the eukaryotic transcription machinery across the yeast genome reveals several unifying principles of pre-initiation complexes at coding and non-coding genes.
Center NamePennsylvania State University