Study Detail

TitlemiR-221 is required for endothelial tip cell behaviors during vascular development
Study TypeTranscriptome Analysis
Abstract Through deep sequencing and functional screening in zebrafish, we find that miR-221 is essential for angiogenesis. miR-221 knockdown phenocopied defects associated with loss of the tip cell-expressed Flt4 receptor. Furthermore, miR-221 was required for tip cell proliferation and migration, as well .. [more]
Center NameGEO