Study Detail

TitleBRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair
Study TypeOther
Abstract Brca1 is required for DNA repair by homologous recombination (HR) and normal embryonic development. Here we report that deletion of the DNA damage responsefactor 53BP1 overcomes embryonic lethality in Brca1-nullizygous mice, and rescues HR deficiency, as measured by hypersensitivity to PARP (polyADP .. [more]
Center NameGEO