Study Detail

TitleGenome-wide mapping of Runx1-bound sites in early B-cell progenitors
Study TypeOther
Abstract The t(12;21) chromosomal translocation, targeting the gene encoding the RUNX1 transcription factor, is observed in 25% of pediatric acute lymphoblastic leukemia (ALL) and is an initiating event in the disease. To elucidate the mechanism by which RUNX1 disruption initiates leukemogenesis, we investig .. [more]
Center NameGEO