Study Detail

TitleAddiction of t(8;21) and inv(16) AML to native RUNX1 [ChIP-Seq data]
Study TypeOther
Abstract Cancer cells maintain a sensitive balance between growth-promoting oncogenes and apoptosis inhibitors. We show that WT RUNX1 is required for survival of t(8;21)-Kasumi-1 and inv(16)-ME-1 AML cell lines. The malignant AML phenotype is sustained by a delicate AML1-ETO/RUNX1 balance that involves compe .. [more]
Center NameGEO