Study Detail

TitleGenome-Wide Transcriptional Effects of the Anti-Cancer Agent Camptothecin
Study TypeTranscriptome Analysis
Abstract The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalently to DNA in a “cleavable complex”. To examine the effects of camptothecin on RNA synthesis genome-wide we used Bru-Seq and show that camptothecin treatment affected transcription .. [more]
Center NameGEO