Study Detail

TitleTargeting H3K4 methylation as a therapeutic strategy for Huntington''s disease (RNA-seq)
Study TypeTranscriptome Analysis
Abstract Transcriptional dysregulation is an early feature of Huntington''s disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H .. [more]
Center NameGEO